Status:
RECRUITING
Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting
Lead Sponsor:
University of Pittsburgh
Conditions:
Infertility, Male
Cancer
Eligibility:
MALE
Phase:
NA
Brief Summary
Spermatogonial stem cell transplantation through ultrasound guided rete testis injection and testicular tissue grafting will be performed for participants who have frozen testicular tissue prior to go...
Detailed Description
Azoospermia (no sperm in ejaculated semen) impacts 1% of men in the general population and 15% of infertile men, which translates to 645,000 males between the ages of 20 and 50 (prime reproductive yea...
Eligibility Criteria
Inclusion
- Male participant at least in Tanner stage 3
- Previously cryopreserved and stored testicular tissue/cells (frozen due to an infertility-risking diagnosis or treatment such as chemotherapy or radiation) available for autologous transplantation and grafting
- Healthy enough to undergo anesthesia
- Written clearance for the procedure from the patient's hematologist or oncologist to confirm the patient has finished treatment for primary condition and are clear to undergo autologous stem cell transplant
Exclusion
- Participants considered to be high risk for surgical complications
- Participants with a history of leukemia, lymphoma or testicular cancer or a cancer that likely involved testicles at the time of testicular tissue collection
- Diagnosed with psychological, psychiatric, or other conditions which prevent giving fully informed consent.
Key Trial Info
Start Date :
November 10 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2028
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT04452305
Start Date
November 10 2023
End Date
July 1 2028
Last Update
December 10 2025
Active Locations (1)
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1
Magee-Womens Hospital
Pittsburgh, Pennsylvania, United States, 15213