Status:
COMPLETED
The CASCADE Study - Measures of Complement Activation and Inflammation in Patients With Covid-19
Lead Sponsor:
Portsmouth Hospitals NHS Trust
Collaborating Sponsors:
Akari Therapuetics
Conditions:
Coronavirus
Eligibility:
All Genders
18+ years
Brief Summary
COVID-19 is a new disease and therefore it is still not clear exactly how the virus affects the body and why people are affected so differently. It causes infection in the lungs and the virus can then...
Detailed Description
This study is an observational cross-sectional and cohort study to assess whether there is evidence of increased complement activation and/or LTB4 levels and other parameters of inflammation and a pro...
Eligibility Criteria
Inclusion
- \- 1. Adults ≥18 years old requiring hospital admission for COVID-19
- 2\. COVID-19 confirmed by either\*:
- A positive swab (using RT-PCR)
- OR based on a high level of clinical probability confirmed by the presence of typical symptoms and compatible radiological findings on imaging with no alternative cause for these findings identified by the treating physician.
Exclusion
- 1\. Renal replacement therapy on ITU
- 2\. Significant trauma (including an acute fracture or significant head injury)
- 3\. Massive transfusion of blood products
- 4\. Confirmed bacteraemia with pathogenic organism on blood cultures or other severe bacterial infections (including abscess/empyema) which persist despite broad-spectrum antibiotics and are thought to be significantly contributing to the patient's symptoms and clinical state. Recruitment will not be delayed however pending a negative culture.
Key Trial Info
Start Date :
May 28 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 30 2021
Estimated Enrollment :
72 Patients enrolled
Trial Details
Trial ID
NCT04453527
Start Date
May 28 2020
End Date
May 30 2021
Last Update
April 7 2023
Active Locations (1)
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1
Portsmouth Hospitals NHS Trust
Portsmouth, United Kingdom, PO6 3LY