Status:
COMPLETED
Impact of Palliative Transfusions on Quality of Life in Patients With Blood Cancers on Hospice
Lead Sponsor:
University of Oklahoma
Conditions:
Hematologic Malignancy
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this pilot research study is to evaluate the effectiveness of blood and platelet transfusions in improving symptoms and quality of life of patients enrolled in hospice.
Detailed Description
This is a non-randomized pilot study to investigate the feasibility of symptom-based blood transfusion in patients with hematologic malignancies enrolling in hospice care. The study will be a case se...
Eligibility Criteria
Inclusion
- Patients \>= 18 years irrespective of their race, sex and/or other medical history.
- All patients \>= 18 years with a primary diagnosis of acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), chronic myelomonocytic leukemia (CMML), "high risk" Non-Hodgkin's Lymphoma (NHL), multiple myeloma (MM) and Myelodysplastic Syndrome (MDS) with a life expectancy of \< 6 months who are transfusion dependent. Criteria for transfusion dependence is Symptom Questionnaire symptom grade 2 or higher. The Symptom Questionnaire is based on CTCAE (Common Terminology Criteria for Adverse Events) v5.0, with criteria modified for palliative care patients.
- Patients wanting to enroll in hospice.
- Availability of peripheral IV access line or patient agrees to have semi-permanent IV line placed.
Exclusion
- Patients with \> 6-month survival.
- Patients unwilling to go on hospice.
- Patients with antibodies to blood or platelets that would preclude ability to give blood/platelets without prolonged blood typing and or need for anti-HLA platelets.
Key Trial Info
Start Date :
August 14 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 17 2023
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04454723
Start Date
August 14 2020
End Date
August 17 2023
Last Update
March 5 2024
Active Locations (1)
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1
Stephenson Cancer Center
Oklahoma City, Oklahoma, United States, 73117