Status:
COMPLETED
Impact of PH Values of the Embryo Culture Medium on Success of in Vitro Fertilization (IVF)
Lead Sponsor:
University Hospital, Toulouse
Conditions:
Embryo Growth Disorder
Humans
Eligibility:
FEMALE
18-40 years
Phase:
NA
Brief Summary
The objective of this study is to compare, through a multicentric randomized trial, the impact of two pH values in the embryo culture medium on the clinical results of In Vitro Fertilization (IVF) pro...
Detailed Description
Despite progress in Assisted Reproductive Technology (ART), the livebirth rate per oocyte retrieval during In Vitro Fertilization (IVF) remain relatively low (15 à 25%). This is in part due to the sen...
Eligibility Criteria
Inclusion
- Couples whose woman is 18 to 40 years old and man is 18 to 60 at the time of inclusion.
- Infertile couple with a medical indication of IVF-ICSI according to criteria applied in each center.
- First or second ICSI attempt with fresh embryo transfer.
- Signature of informed consent by both partners of the couple
- Affiliation to a social security scheme or equivalent for both partners of the couple.
- Fitting the inclusion criteria for IVF according the the French law.
Exclusion
- Use of spermatozoa extracted by testicular biopsy.
- Freeze-al strategy (without fresh embryo transfer) decided before embryo culture
- Absence of mature oocyte (metaphase II) at the day of the puncture
- Uterine pathology affecting implantation (uterine malformation, diffuse adenomyosis ...)
- One of the two partners (or both) is (are) infected with HIV, HCV or HBV in the year before the inclusion
- One of the two partners (or both) is (are) in safeguarding justice, under guardianship or trusteeship.
- Couple having already participated once in the study.
- Couple enrolled in another interventional clinical study
Key Trial Info
Start Date :
October 14 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 19 2024
Estimated Enrollment :
429 Patients enrolled
Trial Details
Trial ID
NCT04456478
Start Date
October 14 2020
End Date
June 19 2024
Last Update
January 13 2025
Active Locations (3)
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1
CHU de BORDEAUX
Bordeaux, France
2
Centre AMP BIOPYRENEES
Pau, France
3
CHU de TOULOUSE
Toulouse, France