Status:
UNKNOWN
The Clinical Value of the Nitric Oxide System Components in Asthma and COPD
Lead Sponsor:
Ryazan State Medical University
Conditions:
Asthma
COPD
Eligibility:
All Genders
18-70 years
Brief Summary
It is planned to conduct a study of nitric oxide metabolites (nitrates and nitrites), L-arginine, arginase-1, and asymmetric dimethylarginine in patients with bronchial asthma and chronic obstructive ...
Detailed Description
Chronic obstructive pulmonary disease and bronchial asthma have a leading position among respiratory diseases. A significant contribution to the clinical picture and long-term prognosis is made by exa...
Eligibility Criteria
Inclusion
- men and women aged between 18 and 70 years
- a diagnosis of asthma or chronic obstructive pulmonary disease according to actual GINA and GOLD guidelines
Exclusion
- decompensated pathology of the cardiovascular system;
- history of liver dysfunction accompanied by an increase in ALT, AST or total bilirubin more than 3 times higher than the upper limit of normal;
- history of severe renal impairment, accompanied by a decrease in glomerular filtration rate below 60 ml/min (according to CKD-EPI);
- abuse on psychoactive substances and / or alcohol.
Key Trial Info
Start Date :
September 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 30 2025
Estimated Enrollment :
240 Patients enrolled
Trial Details
Trial ID
NCT04456491
Start Date
September 1 2021
End Date
June 30 2025
Last Update
July 21 2023
Active Locations (1)
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1
Department of Therapy
Ryazan, Ryazanskaya Obl., Russia, 390026