Status:
TERMINATED
Genetic and Dietary Predictors of Anti-platelet Response
Lead Sponsor:
University of Washington
Collaborating Sponsors:
Southcentral Foundation
University of Montana
Conditions:
Platelet Function
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
This study will investigate differences in platelet aggregation under basal and aspirin-treated conditions in American Indian and Alaska Native people who have extreme levels (low and high) of n-3 pol...
Detailed Description
Purpose: In this aim, the investigators will test the hypothesis that n-3 PUFAs modify aspirin anti-platelet response, by measuring and comparing three different indicators of aspirin response in indi...
Eligibility Criteria
Inclusion
- Participants with no history of significant medical conditions including cardiac, pulmonary, hepatic, gastrointestinal, or renal disease, or HIV.
- Participants will be males or females, 18 years or older.
- Participants will be self-identified as: Yup'ik or Cup'ik (YK-Delta), AI/AN (SCF), or a member of the Confederated Salish and Kootenai Tribe (Flathead Reservation).
- Participants must read and understand English or Yup'ik.
- Participants must be able to provide informed consent.
Exclusion
- Participants with any significant chronic medical condition, including cardiac, pulmonary, hepatic, gastrointestinal, or renal disease, or HIV.
- Participants less than 18 yrs of age.
- Participants unable to read and understand English or Yup'ik.
- Participants unable to provide informed consent.
- Recent (within 2 weeks) use of aspirin, NSAIDs, antihistamines, or any prescription anticoagulant drug such as warfarin.
Key Trial Info
Start Date :
August 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 31 2023
Estimated Enrollment :
126 Patients enrolled
Trial Details
Trial ID
NCT04456608
Start Date
August 1 2016
End Date
July 31 2023
Last Update
December 15 2023
Active Locations (3)
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1
Southcentral Foundation
Anchorage, Alaska, United States, 99508
2
University of Montana
Missoula, Montana, United States, 59812
3
Oregon Health & Sciences University
Portland, Oregon, United States, 97239