Status:
UNKNOWN
Effect of Preoperative Intervention With Folic Acid and Vitamin B12 on Postoperative Neurobehavioral Changes in Children
Lead Sponsor:
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Conditions:
Delirium
Eligibility:
All Genders
6-24 years
Phase:
NA
Brief Summary
Comparison of preoperative folic acid and VitB12 intervention on postoperative delirium and long-term neurobehavioral changes in children under general anesthesia
Detailed Description
Folic acid, as a one-carbon unit transferase coenzyme, participates in the synthesis of purine and thymine, and is an important element of the nervous system. Vitamin B12 participates in methyl conver...
Eligibility Criteria
Inclusion
- ASA grade is Ⅰ \~ Ⅱ;
- Children aged 6 months to 2 years old;
- It is planned to undergo head, neck and maxillofacial surgery under general anesthesia with anesthesia for less than 6 hours
Exclusion
- Children with a history of respiratory tract infection within 1 week;
- Children with congenital malformations such as congenital heart disease;
- Children with central nervous system diseases or mental disorders or mental disorders;
- Children with long-term use of sedative or analgesic drugs;
- Children with severe liver and kidney dysfunction;
- Received folic acid and VitB12 supplement treatment or taken related derivatives;
- Have taken drugs that affect absorption within the past month, such as sulfonamides, aspirin, etc .;
- Those who have participated in other relevant clinical research in the past 3 months;
- Children with stunting
Key Trial Info
Start Date :
June 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2025
Estimated Enrollment :
360 Patients enrolled
Trial Details
Trial ID
NCT04456985
Start Date
June 1 2020
End Date
June 30 2025
Last Update
July 7 2020
Active Locations (1)
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1
China
Shanghai, Shanghai Municipality, China, 200001