Status:
UNKNOWN
Mechanically-Assisted and Non-Invasive Ventilation for Breathing-related Tumor Motion Mitigation.
Lead Sponsor:
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Conditions:
Optimization of Motion Mitigation Strategies by Mechanically-Assisted Non-Invasive Ventilation
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Breathing motion still remains a major issue that jeopardizes the accuracy of photon- and proton-therapy for thoracic and upper-abdominal tumors, which represent up to 40% of curative radiotherapy tre...
Detailed Description
Radiotherapy of mobile tumors faces many challenges due to breathing-related geometrical uncertainties. Breathing amplitude and frequency may deeply and unexpectedly vary from cycle to cycle, during a...
Eligibility Criteria
Inclusion
- Validation of the MANIV-optimized gating strategy for breasrt tumors :
- Patients with left breast tumors eligible for radiation therapy with breath hold technique.
- Validation of the MANIV optimized Gating strategy for lung/liver tumors:
- Patients with lung (primary or secondary) or liver (primary or secondary) tumors eligible for stereotactic radiation therapy.
- Validation of the MANIV-optimized Tracking strategy for liver tumors:
- Part 1: Patients with hepatic neoplasia (primary or secondary) eligible for stereotactic radiation therapy on the Cyberknife® of the Oscar Lambret center in Lille (France)..
- Part 2: Patients with hepatic neoplasia (primary or secondary) treated by respiratory tracking on the Cyberknife® of the Oscar Lambret center in Lille (France).
- 4 - Evaluation of a proton therapy treatment delivered in silico to mobile tumors with MANIV in DIBH mode : Patients included in the study on the optimization of the Gating strategy.
Exclusion
- history of spontaneous pneumothorax
Key Trial Info
Start Date :
July 3 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2024
Estimated Enrollment :
241 Patients enrolled
Trial Details
Trial ID
NCT04457102
Start Date
July 3 2020
End Date
September 30 2024
Last Update
June 1 2023
Active Locations (1)
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1
Cliniques Universitaires Saint-Luc
Woluwe-Saint-Lambert, Brussels Capital, Belgium, 1200