Status:
ACTIVE_NOT_RECRUITING
Cognitive Changes and Neural Correlates After Rehabilitation of Masticatory Function in Elderly -an Intervention Study
Lead Sponsor:
Folktandvården Stockholms län AB
Collaborating Sponsors:
Karolinska Institutet
Eastmaninstitutet
Conditions:
Chewing Problem
Cognitive Decline
Eligibility:
All Genders
65-80 years
Phase:
NA
Brief Summary
Today in elderly tooth loss and loss of oral function is widespread, but it is an underexplored modifiable risk factor potentially contributing to the development of dementia. In this interventional s...
Detailed Description
* Dementia is a general term of several neurodegenerative diseases that jointly affects approximately 7% of the general population older than 65 years, and 30% older than 80 years (O'Brien, 2003). Imp...
Eligibility Criteria
Inclusion
- 65-80 years of age at start
- Impaired chewing ability (Eichner index B2-B4, C1-C4)
- Dental rehabilitation with fixed prosthodontics, implant and/or tooth supported (overdentures included) \>10 occluding units
- Mini Mental State Examination (MMSE) score \>25
Exclusion
- Brain trauma or stroke \<6 months
- Neurological disease (stroke, dementia, Alzheimer disease, Parkinson disease).
- Intellectual disability
- Psychological disorders
- Participants with chronic pain, depression or sleeping disorders
- Daily analgesic medication that may affect cognitive and/or executive performance of the brain
- Poor Swedish language skills, reading disabilities
- Severely reduced hearing or vision
- Prosthetic treatment with removable dentures (full or partial)
- MRI exclusion criteria:
- Claustrophobia
- Difficulties in lying down in a supine position for about an hour, or any other difficulties related to the MRI head coil
- Participants with metal or medical implants in the body contraindicating MRI scan
Key Trial Info
Start Date :
November 2 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2027
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04458207
Start Date
November 2 2018
End Date
December 30 2027
Last Update
September 26 2025
Active Locations (2)
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1
Eastmaninstitutet Folktandvården Stockholm AB
Stockholm, Stockholm County, Sweden, 11324
2
Eastmaninsitutet, Department of Prosthodontics
Stockholm, Sweden, 11324