Status:
COMPLETED
MIKROBE Management of Infected Knee Replacements-Obtaining Best Evidence
Lead Sponsor:
Royal Devon and Exeter NHS Foundation Trust
Collaborating Sponsors:
University of Exeter
Nuffield Orthopaedic Centre NHS Trust
Conditions:
Arthroplasty, Replacement, Knee
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Following a prosthetic knee joint infection, two types of operative approach can be undertaken to treat the infection: a one-stage or two-stage revision operation. Both approaches are widely used and ...
Eligibility Criteria
Inclusion
- Adults with prosthetic knee infection suitable for either one-stage or two-stage revision surgery
- Intra-operatively, all cases must have adequate soft-tissue coverage post debridement to allow single or two stage revision surgery.
- Case meets the International Consensus Meeting criteria for infection
- Patients having had a Debridement, Anti-biotic and Implant Retained procedure previously or washout/biopsy only of an infected TKR are suitable
Exclusion
- Unable or unwilling to undergo either treatment
- Lacking capacity to consent to research
- Refusal to consent to study for any reason
- Re-revision of prosthetic knee infection if first revision was for infection
- Presence of tuberculosis infection
Key Trial Info
Start Date :
November 17 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 30 2023
Estimated Enrollment :
3 Patients enrolled
Trial Details
Trial ID
NCT04458961
Start Date
November 17 2020
End Date
January 30 2023
Last Update
November 18 2023
Active Locations (2)
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1
Princess Elizabeth Orthopaedic Centre, Royal Devon and Exeter NHS Trust (RD&E NHSFT)
Exeter, Devon, United Kingdom, EX2 5DW
2
Nuffiels Orthopaedic Centre (NOC)
Oxford, United Kingdom