Status:
COMPLETED
Ketamine Analgesia in Third Molar Surgery
Lead Sponsor:
Dalarna County Council, Sweden
Collaborating Sponsors:
Uppsala University
Center for Clinical Research Dalarna, Sweden
Conditions:
Pain
Postoperative
Eligibility:
All Genders
18-44 years
Phase:
PHASE4
Brief Summary
BACKGROUND AND PURPOSE Outpatient surgery (day case surgery) is increasing. When the patients go home on the same day, this demands safe pain relief. A reduction of morphine (opioid) use is sought bec...
Eligibility Criteria
Inclusion
- Healthy or mild well-compensated systemic disease (ASA I \& II)
- 18- \<45 years
- 50-100 kg body weight
Exclusion
- Medication drugs: analgesics, hypnotics (the last week before surgery), thyroid hormones, psychoactive drugs or monoamine oxidase inhibitors (MAO inhibitors).
- Hypertension \[\> 150/95 mmHg in screening study\]
- Heart failure
- Psychosis
- Epilepsy
- Hyperthyreosis
- Myasthenia gravis
- Glaucoma
- Verified sleep apnea
- Diabetes (insulin treated)
- Porphyria
- Pregnancy
- Breast-feeding
- Blood transmitted infections, such as HIV and hepatitis B and C
- Known hypersensitivity to midazolam, ketamine, ibuprofen, or local anesthetics
- Inability to obtain the requisite written or oral information
Key Trial Info
Start Date :
February 14 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 30 2022
Estimated Enrollment :
168 Patients enrolled
Trial Details
Trial ID
NCT04459377
Start Date
February 14 2017
End Date
September 30 2022
Last Update
October 12 2022
Active Locations (1)
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1
Käkkirurgiska kliniken, Falu lasarett
Falun, Dalarna County, Sweden, 79182