Status:
RECRUITING
RecruitmEnt Assessed by eleCtRical Impedance Tomography
Lead Sponsor:
Unity Health Toronto
Conditions:
Acute Respiratory Distress Syndrome (ARDS)
Eligibility:
All Genders
18+ years
Brief Summary
The RECRUIT study is a multinational, multicenter physiological observational study conducted by the PLUG working group. It is a single-day study (1.5-2 hours) associated with specific lung (de)recrui...
Detailed Description
Despite higher positive end-expiratory pressure (PEEP) being associated with multiple physiologic benefits, randomized clinical trials comparing higher vs. lower PEEP levels failed to show improved su...
Eligibility Criteria
Inclusion
- Intubated moderate and severe ARDS according to the Berlin definition (PaO2/FiO2 ratio \<= 200 mmHg)
- Under continuous sedation with or without paralysis
Exclusion
- Age \<18 years
- Bronchopleural fistula
- Pure COPD exacerbation
- Contraindication to EIT monitoring (e.g. burns, pacemaker, thoracic wounds limiting electrode belt placement)
- Hemodynamic instability (Systolic BP \< 75 mmHg or MAP \< 60 mmHg despite vasopressors and/or heart rate \< 55 bpm)
- Attending physician deems the transient application of high airway pressures to be unsafe
Key Trial Info
Start Date :
June 9 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2027
Estimated Enrollment :
171 Patients enrolled
Trial Details
Trial ID
NCT04460859
Start Date
June 9 2020
End Date
June 1 2027
Last Update
May 20 2025
Active Locations (4)
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1
Faculdade de Medicina da University São Paulo
São Paulo, Brazil
2
St. Michael's Hospital
Toronto, Ontario, Canada, M5B1T8
3
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Milan, Italy
4
Vall d'Hebron University Hospital
Barcelona, Spain