Status:
COMPLETED
The Effect of the Interaction of Glucagon and Insulin on Endogenous Glucose Production in Humans
Lead Sponsor:
Adrian Vella
Conditions:
Healthy
Eligibility:
All Genders
18-40 years
Phase:
PHASE3
Brief Summary
The purpose of this research is to help understand the relative importance of changes in insulin secretion (which lowers glucose) and changes in glucagon (which raises glucose) to regulate metabolism ...
Detailed Description
Study A (Insulin 0.4mU/Kg/min): Subjects will be admitted to the CRTU at approximately 1700 on the day prior to study. They will then consume a standard 10kcal/kg meal (55% carbohydrate, 30% fat, 15% ...
Eligibility Criteria
Inclusion
- We will recruit 15 otherwise healthy subjects using intramural and local extramural advertising after approval from the Mayo Clinic Institutional Review Board. Individuals who express interest in participating will be invited for a screening visit. Individuals with a BMI \< 19 or \> 28 kg/m2 will be excluded from the study to avoid potential confounding effects that may result from extreme leanness or from obesity. Subjects will have no known systemic illness, taking any medication that could affect glucose metabolism and no history of upper gastrointestinal surgery.
Exclusion
- Subjects \< 18 years of age or \> 40 years of age will not be studied to minimize the potential confounding effects of age on glucagon and insulin action. The subjects will not be taking medications that affect glucose metabolism (to be determined by PI) and have no history of chronic illness or upper gastrointestinal surgery. We are seeking to recruit subjects who do not have diabetes (fasting glucose \<100mg/dL).
Key Trial Info
Start Date :
October 14 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 6 2022
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT04461015
Start Date
October 14 2020
End Date
January 6 2022
Last Update
June 21 2022
Active Locations (1)
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1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905