Status:
COMPLETED
Comparison of CRP Levels, Neutrophil Count, and Clinical Outcomes of Low Dose Ketamine Between at Anesthesia Induction and at the End of Surgery in Patients Undergo Elective Laparotomy
Lead Sponsor:
Udayana University
Conditions:
General Anesthesia
Laparotomy
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The effects of anesthesia and surgery can lead to stress responses that result in hormonal and metabolic changes in the body. The immune system and the nervous system communicate both ways, and it was...
Detailed Description
The effects of anesthesia and surgery can lead to stress responses that result in hormonal and metabolic changes in the body. The immune system and the nervous system communicate both ways, and it was...
Eligibility Criteria
Inclusion
- Patients undergoing elective laparotomy with general anesthesia at Sanglah Hospital from July to September 2020.
- Patients aged 18-65 years.
- Patient physical status American American Society of Anesthesiologist (ASA) 1 and 2.
Exclusion
- Contraindication to ketamine.
- Allergy to morphine
- Presence of cardiorespiratory chronic diseases.
- Presence of autoimmune diseases.
- History of the central nervous system or psychiatric disorders.
- BMI \<18.5 kg/m2 or ≥30 kg/m2.
- A history of chronic pain killer medications (such as opioid or non-steroidal anti- inflammatory drugs)
- Drop Out Criteria
- Patients with class 3 bleeding during the surgery
- Patients with more than 5-hours duration of surgery
- Patients need mechanical ventilation after the surgery
Key Trial Info
Start Date :
July 27 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 10 2020
Estimated Enrollment :
68 Patients enrolled
Trial Details
Trial ID
NCT04462094
Start Date
July 27 2020
End Date
November 10 2020
Last Update
November 12 2020
Active Locations (1)
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1
Sanglah General Hospital
Denpasar, Bali, Indonesia, 80114