Status:
COMPLETED
Recombinant Human Platelet-derived Growth Factor in Combination With Collagen Matrix
Lead Sponsor:
University of Michigan
Conditions:
Gingival Recession
Platelet Derived Growth Factor
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The present randomized clinical trial is aimed at evaluating the efficacy of recombinant human platelet-derived growth factor in combination with collagen matrix for the treatment of multiple adjacent...
Detailed Description
Despite the fact that gingival recession is most often a generalized condition rather than being localized to a single tooth, most of the data currently found in the literature pertains to the treatme...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Periodontally and systemically healthy
- Full-mouth plaque score and full-mouth bleeding score ≤ 20% (measured at four sites per tooth)
- At least two multiple adjacent gingival recessions (with at least one 2 mm or deeper) requiring surgical intervention for root coverage
- No interproximal attachment/bone loss
- No prior experience of root coverage procedures within the last 1 year
- The patient must be able to perform good oral hygiene
Exclusion
- Contraindications for periodontal surgery
- Patients pregnant or attempting to get pregnant (self-reported)
- Untreated periodontitis
- Persistence of uncorrected gingival trauma from traumatic toothbrushing
- Interdental attachment loss greater than 1 mm or furcation involvement in the teeth to be treated
- Presence of severe tooth malposition, rotation or clinically significant super-eruption
- Self-reported current smoking more than 10 cigarettes/day or pipe or cigar smoking
- Allergy to collagen-based medical products
Key Trial Info
Start Date :
September 9 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 18 2021
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04462237
Start Date
September 9 2020
End Date
August 18 2021
Last Update
September 28 2021
Active Locations (1)
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1
University of Michigan School of Dentistry
Ann Arbor, Michigan, United States, 48104