Status:
UNKNOWN
Association of Single Nucleotide Polymorphisms (SNPs) in Metalloproteinases (MMPs) Genes With the Risk of Primary Knee Osteoarthritis in Greek Population.
Lead Sponsor:
Aristotle University Of Thessaloniki
Conditions:
Metalloproteinase SNPs -1575 G/A MMP-2, 836 A/G MMP-9 and -77 A/G MMP-13 and Risk for Developing Knee Osteoarthritis in Greek Population
Eligibility:
All Genders
55-80 years
Brief Summary
Does the presence of gene polymorphisms -1575G / A in the MMP-2 gene, 836A / G in the MMP-9 gene and -77A / G in the MMP-13 gene, affect the risk of developing idiopathic knee osteoarthritis in the Gr...
Detailed Description
This is a prospective case-control study in which the patients' genotype will be studied against the genotype of the controls. The study is prospective and not retrospective, as data will be collected...
Eligibility Criteria
Inclusion
- Patients with primary knee osteoarthritis are selected based on clinical symptoms and radiological imaging with a score at least 2 on the Kellgren \& Lawrence scale.
- Patients without symptomatology or radiographic image of knee osteoarthritis (score \<2 on Kellgren \& Lawrence scale) will be selected as controls.
Exclusion
- systemic inflammatory disease
- rheumatic disease
- liver disease
- renal failure
- neoplasm or other chronic disease
Key Trial Info
Start Date :
July 6 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2022
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT04463290
Start Date
July 6 2020
End Date
December 30 2022
Last Update
August 18 2022
Active Locations (1)
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1
3rd Orthopedic Department , Pagageorgiou Hospital
Thessaloniki, Athens, Greece, 56403