Status:
COMPLETED
The Influence of Coronary Chronic Total Occlusion on Myocardial Perfusion on Computed Tomography
Lead Sponsor:
National Institute of Cardiology, Warsaw, Poland
Conditions:
Coronary Occlusion
Myocardial Ischemia
Eligibility:
All Genders
18+ years
Brief Summary
The COPACABANA study is designed as a single-centre, open, prospective trial aimed to assess the influence of coronary chronic total occlusion (CTO) on downstream myocardial ischemia via the novel com...
Eligibility Criteria
Inclusion
- delivery of an informed consent and compliance with study protocol
- persistent angina pectoris (CCS class ≥2) refractory to optimal medical therapy
- CTO of a major coronary artery (left anterior descending artery, right coronary artery, left circumflex artery) of at least 2.5 mm vessel diameter confirmed by invasive angiography
- preserved left ventricular ejection fraction (\>50%) on echocardiography or cardiac magnetic resonance with preserved contractility in the CTO territory (normokinesia and/or hypokinesia)
Exclusion
- unstable angina and/or myocardial infarction
- prior myocardial infarction within 4 weeks before study enrolment
- occurrence of myocardial infarction and/or unplanned revascularization between the index procedure and post-procedural CTP study
- impaired renal function (eGFR ≤45 ml/min/m2)
- contraindications to antiplatelet therapy and/or heparin
- other contraindications to CTP (pregnancy, allergy to contrast media or pharmacologic stress agents, tachyarrhythmia, claustrophobia)
Key Trial Info
Start Date :
February 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2022
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT04465526
Start Date
February 1 2020
End Date
July 1 2022
Last Update
February 16 2024
Active Locations (1)
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1
National Institute of Cardiology
Warsaw, Poland, 04-628