Status:
COMPLETED
Safety and Efficacy of Allogeneic Adipose Tissue Mesenchymal Stem Cells in Diabetic Patients With Critical Limb Ischemia
Lead Sponsor:
Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Collaborating Sponsors:
Clinica Universidad de Navarra, Universidad de Navarra
Hospital Universitario La Paz
Conditions:
Limb Ischemia
Diabetic Foot
Eligibility:
All Genders
40-90 years
Phase:
PHASE2
Brief Summary
Phase II national, multicenter, double-blind, randomized, placebo-controlled, phase-3 clinical trial of 3 parallel groups.
Detailed Description
Disease or disorder under study: Critical ischemia of the lower limbs in diabetic patients without the possibility of revascularization. Main valuation variable: Proportion of Adverse Events related ...
Eligibility Criteria
Inclusion
- Patients must meet ALL of the following criteria to be included in the study:
- Patients of both sexes.
- Age between 40 and 90 years.
- Severe grade vascular arteriosclerosis (category RB 4 and 5 mono or bilateral).
- Impossibility of surgical or endovascular revascularization or failure in revascularization surgery performed, at least 30 days before inclusion in the study, defining failure as direct non-arrival of vessels to the plantar arch.
- Normal biochemical parameters defined by:
- Leukocytes\> 3000 / mm3
- Neutrophils\> 1500 / mm3
- Platelets\> 100,000 / mm3
- AST / ALT \<2.5x upper limit of normal
- In patients with an ischemic ulcer, it must be stable for at least 1 week.
- Patients under conventional medical treatment for CLI.
- Women of childbearing age must obtain a negative result in a urine pregnancy test performed at the time of inclusion in the study and commit to using an effective contraceptive method during their participation in the study.
- Patients who have not participated in any other clinical trial during the 3 months prior to the inclusion visit.
- Patients who sign the informed consent.
Exclusion
- Patients who present SOME of the following criteria may not be selected to participate in this study:
- CLI with tissue loss in the target member (category 6 of RB).
- Previous major amputation in the target member.
- Uncontrolled hypertension (defined as PAS\> 180 or PAD\> 110 in at least 2 determinations during the selection period).
- Patients with severe heart failure or ejection fraction less than 30%.
- Patients with a previous diagnosis of ventricular arrhythmias or unstable angina.
- Patients with septicemia.
- Patients diagnosed with deep vein thrombosis in the 3 months prior to their inclusion in the study.
- Concomitant therapy that includes hyperbaric oxygen, angiogenic agents or Cox II inhibitors.
- Contraindication to perfusion NMR.
- Proliferative retinopathy without treatment.
- Diabetic nephropathy in hemodialysis.
- Patients previously treated with cell therapy, gene therapy or growth factors in the last year.
- Concomitant disease that limits life expectancy to 1 year or that does not ensure the follow-up period.
- Patients who have suffered a stroke or myocardial infarction in the 3 months prior to the inclusion visit.
- Severe anemia (hemoglobin \<7.9g / dl) in the inclusion analysis.
- Patients with a previous diagnosis of chronic alcoholism.
- Any clinically significant anomaly detected in the Selection Period and which, in the opinion of the investigator, constitutes an impediment to the correct participation of the patient in the study or the fulfillment of the procedures established therein.
Key Trial Info
Start Date :
January 11 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 5 2024
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT04466007
Start Date
January 11 2021
End Date
December 5 2024
Last Update
April 27 2025
Active Locations (10)
Enter a location and click search to find clinical trials sorted by distance.
1
Hospital General de Alicante
Alicante, Spain
2
Hospital Gregorio Marañon
Madrid, Spain
3
Hospital Universitario Fundacion Jimenez Diaz
Madrid, Spain
4
La Paz University Hospital
Madrid, Spain