Status:
RECRUITING
A Study to Evaluate the Effect of Genetic Variation on Beta-cell Function During Fasting and Hyperglycemia in Nondiabetics
Lead Sponsor:
Adrian Vella
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Healthy
Eligibility:
All Genders
25-65 years
Phase:
PHASE3
Brief Summary
The GLP-1 receptor (GLP1R) gene is found on the beta cells of the pancreas. Its role is in the control of blood sugar level by enhancing insulin secretion from the pancreas after eating a meal. The pu...
Eligibility Criteria
Inclusion
- 40 nondiabetic subjects will be recruited.
- 20 subjects with the AA genotype at rs3765467 and remainder will have the GG genotype.
- Individuals encompassing the age span of 25-65 years.
Exclusion
- Individuals under 25 and over 65 years of age.
Key Trial Info
Start Date :
October 17 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04466566
Start Date
October 17 2022
End Date
December 1 2025
Last Update
October 27 2025
Active Locations (1)
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1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905