Status:
COMPLETED
BRain Energy Activation With Ketones to Prevent Alzheimer's Disease
Lead Sponsor:
Université de Sherbrooke
Collaborating Sponsors:
Alzheimer's Association
Nestle Health Science
Conditions:
MCI
Eligibility:
All Genders
55-80 years
Phase:
NA
Brief Summary
A six month randomized controlled intervention with an exogenous ketone salt (EKS) supplement in mild cognitive impairment. Participants will receive 15 g of the supplement twice daily (equivalent to ...
Eligibility Criteria
Inclusion
- The participant must answer Yes to the question ''Do you think your memory is not as good as it was?''
- Have a MoCA Score between 20/30 and 26/30
- Have a QAF score of less than 9/30
- Understand, read and talk French
- Having good visual and hearing acuity
Exclusion
- Major cognitive decline or neurodegenerative disease.
- Already consuming a daily medium chain triglyceride or ketone supplement.
- Soy, milk, gluten or allergy to the study product
- Controlled or uncontrolled diabetes
- Uncontrolled chronic disease
- Vitamin B12 deficit
- Clinical anomaly in the blood chemistry profile
- QSP-9 score over 19/27
- Taking an anti-cholinergic drugs
- Recent change in medication
- Active cancer in the last 2 years
- General anesthesia in the last 6 months
- history of alcohol abuse or dependence in the last 2 years
- Participation in other interventional or PET research project
- Unable to undergo an MRI or PET scan
- History of kidney stones or hypercalcemia
- History of cardiovascular events or insufficiency
- Renal failure and / or creatinine \<58 umol or\> 110 umol for men and \<46 umol or\> 92 umol for women or if the GFR (glomerular filtration rate) \<60 ml / min / 1.73 m2
- Chronic disease of the digestive system or intestinal malabsorption (celiac disease, chronic pancreatitis, Crohn's disease, etc.)
- Body mass index \<20 or voluntary weight loss of more than 5% in the last 6 months.
Key Trial Info
Start Date :
October 15 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 10 2025
Estimated Enrollment :
65 Patients enrolled
Trial Details
Trial ID
NCT04466735
Start Date
October 15 2020
End Date
March 10 2025
Last Update
June 3 2025
Active Locations (1)
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1
Rearsh Centre on Aging
Sherbrooke, Quebec, Canada, J1H4C4