Status:
COMPLETED
ACEI or ARB and COVID-19 Severity and Mortality in US Veterans
Lead Sponsor:
University of Utah
Collaborating Sponsors:
VA Salt Lake City Health Care System
University of Pennsylvania
Conditions:
Hypertension
COVID
Eligibility:
All Genders
18+ years
Brief Summary
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, enters type II pneumocytes using angiotensin-converting enzyme 2 (ACE2). It is unclear whether ACE inh...
Detailed Description
The Coronavirus Disease 2019 (COVID-19) pandemic has killed \>129,000 Americans as of June 30, 2020. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, e...
Eligibility Criteria
Inclusion
- Positive SARS-CoV-2 test in the outpatient setting (Aim 1) or hospitalized for COVID-19 (Aim 2)
- Meet continuous enrollment criteria (≥1 inpatient or any outpatient encounter in each of the two, six-month periods during the 365 days prior to the index date)
- Do not have data inconsistencies (test patients, not Veterans, multiple death dates in data, or not alive on index date)
- Diagnosed with hypertension at any point prior to the index date
- Had at least one prescription dispensed for an antihypertensive medication in the 90 days prior to the index date
Exclusion
- Aim 1.1 and 2.1 (ACEI/ARB vs. non-ACEI/ARB comparison): diagnosed with a compelling indication for ACEI/ARB at any point prior to the index date (i.e., diabetes, stroke, chronic kidney disease, heart failure with reduced ejection fraction, or coronary heart disease)
- Aim 1.2 and 2.2 (ACE vs. ARB comparison): prescription fills for both an ACEI and an ARB in the 90 days prior to the index date; no prescription fill for an ACEI or an ARB in the 90 days prior to the index date
Key Trial Info
Start Date :
January 19 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2020
Estimated Enrollment :
22213 Patients enrolled
Trial Details
Trial ID
NCT04467931
Start Date
January 19 2020
End Date
December 31 2020
Last Update
April 28 2021
Active Locations (1)
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1
University of Utah
Salt Lake City, Utah, United States, 84112