Status:
COMPLETED
Standard Oxygen Versus High Flow Nasal Cannula Oxygen Therapy in Patients With Acute Hypoxemic Respiratory Failure
Lead Sponsor:
Poitiers University Hospital
Conditions:
Acute Respiratory Failure
Hypoxemic Respiratory Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
First-line therapy of patients with acute respiratory failure consists in oxygen delivery through standard oxygen, high-flow nasal oxygen therapy through cannula or non-invasive ventilation. Non-invas...
Eligibility Criteria
Inclusion
- All consecutive patients older than 18 years with an acute hypoxemic respiratory failure will be enrolled if they meet all the following criteria:
- Respiratory rate \>25 breaths/min whatever the oxygen support
- Pulmonary infiltrate,
- PaO2/FiO2 ≤200 mmHg
- Informed consent from the patient or relatives.
Exclusion
- PaCO2 \> 45 mm Hg
- Need for emergent intubation: pulse oximetry \< 90% with maximum oxygen support, respiratory arrest, cardiac arrest, or Glasgow coma scale below 8 points
- Hemodynamic instability defined by signs of hypoperfusion or use of vasopressors \> 0.3 µg/kg/min
- Glasgow coma scale equal to or below 12 points
- Exacerbation of chronic lung disease including chronic obstructive pulmonary disease (grade 3 or 4 of Gold classification), or another chronic lung disease with long term oxygen or ventilatory support
- Cardiogenic pulmonary edema as main reason for acute respiratory failure
- Coronavirus SARS-2 infection as reason for acute respiratory failure (the SOHO-COVID study has been completed)
- Post-extubation respiratory failure within 7 days after extubation,
- Post-operative patients within 7 days after abdominal or cardiothoracic surgery,
- Do not intubate order;
- Already included in the study, refusal to participate or participation in another interventional study with the same primary outcome.
- Patients without any healthcare insurance scheme or not benefiting from it through a third party,
- Persons under law protection, namely minors, pregnant or breastfeeding women, persons deprived of their liberty by a judicial or administrative decision.
Key Trial Info
Start Date :
January 19 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2024
Estimated Enrollment :
1504 Patients enrolled
Trial Details
Trial ID
NCT04468126
Start Date
January 19 2021
End Date
December 31 2024
Last Update
September 17 2025
Active Locations (1)
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1
CHu Poitiers
Poitiers, France, 86000