Status:
RECRUITING
Transcranial Magnetic Stimulation in Progressive Supranuclear Palsy
Lead Sponsor:
Oregon Health and Science University
Collaborating Sponsors:
National Center of Neuromodulation for Rehabilitation
Collins Medical Trust
Conditions:
Palsy Supranuclear
Supranuclear Palsy, Progressive
Eligibility:
All Genders
40-85 years
Phase:
NA
Brief Summary
The objective of this proposal is to investigate the effect of non-invasive repetitive cerebellar transcranial magnetic stimulation (rTMS) on motor control in progressive supranuclear (PSP). The centr...
Eligibility Criteria
Inclusion
- probable or possible PSP by the revised MDS PSP Criteria (Hoglinger 2017)
- age 40-85 at time of screening
- ability to understand and cooperate with simple instructions in English
- ability to read at 6th grade reading level in English
- ability to stand unassisted for at least 30 seconds and to be able walk independently with a walker
- ability to refrain from new physical and speech therapy programs for the duration of the study
- ability to remain on stable doses of any cholinergic, dopaminergic, serotonergic sedative or NMDA receptor antagonists for the duration of the study
- females of child-bearing age must perform a urine pregnancy test and be on reliable birth control during the course of the study
Exclusion
- other significant neurological or vestibular disorders
- presence of electrically, magnetically or mechanically activated implants or history of injurious metal exposure in eyes, head, or body
Key Trial Info
Start Date :
January 17 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 20 2027
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04468932
Start Date
January 17 2020
End Date
April 20 2027
Last Update
May 29 2025
Active Locations (1)
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1
Oregon Health & Science University
Portland, Oregon, United States, 97239