Status:
ACTIVE_NOT_RECRUITING
Clindamycin and Triamcinolone in People With Glioblastoma to Prevent Skin-Related Side Effects of Tumor Treating Fields
Lead Sponsor:
Memorial Sloan Kettering Cancer Center
Conditions:
Glioblastoma
Recurrent Glioblastoma
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The participants are being treated with Tumor Treating Fields (TTFields) for malignant glioma, and this type of treatment may cause skin-related side effects. This study will test whether using clinda...
Eligibility Criteria
Inclusion
- Age ≥18 years
- Diagnosis of newly diagnosed or recurrent GBM with plan to initiate treatment with TTFields with or without systemic therapy, confirmed by the enrolling institution
- Able to self-administer topical interventions or has available another person who can apply the topical agents
- Treatment with TTF should be initiated within 7 days of planned initiation on this trial.
Exclusion
- Known history of allergy to any ingredient of the study agents
- Preexisting scalp disorders such as psoriasis or dermatitis that, in the opinion of the investigator, will affect the grading of skin adverse events, confirmed by enrolling institution.
- Use of concurrent topical therapy to the scalp for another dermatologic condition
- Active, uncontrolled infection requiring systemic or oral antibiotic therapy within 14 days of enrollment
- Use of greater than 4 mg dexamethasone a day within 14 days of enrollment
- Malignant glioma
- Pregnant Women
Key Trial Info
Start Date :
July 9 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2026
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT04469075
Start Date
July 9 2020
End Date
July 1 2026
Last Update
August 8 2025
Active Locations (8)
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1
Northwestern University
Evanston, Illinois, United States, 60208
2
Tufts Medical Center
Boston, Massachusetts, United States, 02111
3
Washington University School of Medicine
St Louis, Missouri, United States, 63110
4
Hackensack Meridian Health
Hackensack, New Jersey, United States, 07601