Status:
COMPLETED
Multidisciplinary Study of Novel NMDA Modulation for Neurodegenerative Disorder
Lead Sponsor:
China Medical University Hospital
Collaborating Sponsors:
Ministry of Science and Technology, Taiwan
Conditions:
Parkinson's Disease With Dementia
Eligibility:
All Genders
50-90 years
Phase:
PHASE2
Brief Summary
Alzheimer's disease (AD) and Parkinson's disease (PD) are currently the leading neurodegenerative disorders. Considering the fact that aged population is rapidly growing, it has become a critical issu...
Detailed Description
Alzheimer's disease (AD) and Parkinson's disease (PD) are currently the leading neurodegenerative disorders. Despite some therapeutic benefits from the medications targeting at cholinergic and dopamin...
Eligibility Criteria
Inclusion
- PD-D will be diagnosed according to the criteria proposed by Movement Disorder Society task force statement. (Emre et al. 2007) . The following wordings are modified from the task force statement. I. Core features
- Diagnosis of PD according to Queen Square Brain Bank criteria
- A dementia syndrome with insidious onset and slow progression, developing within the context of established PD and diagnosed by history, clinical, and mental examination, defined as:
- Impairment in more than one cognitive domain
- Representing a decline from premorbid level
- Deficits severe enough to impair daily life, independent of the impairment ascribable to motor or autonomic symptoms
- MMSE score between 10-26.
- II. Associated clinical features
- Cognitive features: Impaired attention, executive functions, visuo-spatial functions or memory. Core functions of language are largely preserved.
- Behavioral features:
- Apathy
- Changes in personality and mood
- Hallucination• Delusions
- Excessive daytime sleepiness
- III. Features which do not exclude PD-D, but make the diagnosis uncertain
- Co-existence of any other abnormality which may by itself cause cognitive impairment, but judged not to be the cause of dementia.
- Time interval between the development of motor and cognitive symptoms is uncertain
- IV. Features suggesting other conditions or diseases as cause of mental impairment, which, when present make it impossible to reliably diagnose PD-D
- Cognitive and behavioral symptoms appearing solely in the context of other conditions such as:
- Acute confusion due to systemic illnesses or drug intoxication.
- Major depression
- Features compatible with "Probable Vascular dementia" criteria according to NINDS-AIREN Criteria for the diagnosis of probable and possible PD-D \[Probable PD-D\] Both core features must be present. In associated clinical features, typical profile of cognitive deficits should be present in at least 2 of the 4 core cognitive domains. The presence of at least one behavioral symptom supports the diagnosis of probable PD-D. None of group III and IV features is present. \[Possible PD-D\] Both core features must be present. In associated clinical features, the cognitive impairment is atypical in one or more domains. The behavioral symptoms are not necessary to be present. One or more of the group III features may be present. No group IV feature is allowed to be present.
Exclusion
- Patients with uncontrollable malignancy, severe heart failure, uremia under hemodialysis, or decompensated liver cirrhosis.
- Patients taking anticholinergics within 30 days of recruitment.
Key Trial Info
Start Date :
April 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2025
Estimated Enrollment :
61 Patients enrolled
Trial Details
Trial ID
NCT04470037
Start Date
April 1 2016
End Date
September 1 2025
Last Update
November 19 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Psychiatry, China Medical University Hospital
Taichung, Taiwan