Status:
COMPLETED
Point Of Care With Serial NT-proBNP Measurement in Patients With Acute Decompensation of Heart Failure
Lead Sponsor:
Prof. Dr. Jörg Leuppi
Conditions:
Acute Decompensated Heart Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this study is to explore whether the availability of serial NT-proBNP measurements together with safety parameters such as electrolytes and creatinine may influence treatment decision in p...
Detailed Description
The proposed study is a prospective, unblinded, single center, 2-arm randomized controlled pilot trial. In the intervention arm serial measurement of NT-proBNP will be made available to the treating p...
Eligibility Criteria
Inclusion
- Signed informed consent
- NYHA functional class II or III
- Symptoms of heart failure:
- E.g.: Dyspnea Paroxysmal nocturnal dyspnea Reduced exercise capacity Fatigue Extended recovery after exercising Peripheral edema (lower leg, ankle) NT-proBNP \>300 (pg/ml)
- Age \> 18 Years
Exclusion
- NYHA functional class I or IV
- NT-proBNP \< 1200 pg/ml and creatinine clearance \< 60 ml/min (Clearance (ml/min) = 1.23(women 1.03) x body weight (Kg) x (140-Age)/ creatinine (umol/L)) Creatinine clearence: \_\_\_\_\_\_\_\_\_\_\_ \<60ml/min
- Heart failure due to chemotherapeutic drugs
- Uncontrolled brady- or tachyarrythmia
- Unstable angina pectoris
- Severe uncorrected valvular disease
- Planned cardiac intervention in the next 6 months
- Clinically significant concomitant disease states:
- On-going cancer treatment
- Active infection
- Immunosuppressive medical therapy
- Known or suspected non-compliance, drug or alcohol abuse
- Inability to follow the study procedures (Due to language problems, psychological disorders, dementia, etc.)
- Participation in another intervention study
- Enrolment of investigators or their family members
- Pregnancy, lactation, breast feeding
- Positive pregnancy test for females in childbearing age
Key Trial Info
Start Date :
January 23 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 20 2020
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT04471610
Start Date
January 23 2018
End Date
May 20 2020
Last Update
July 17 2020
Active Locations (1)
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1
Cantonal Hospital Baselland Liestal
Liestal, Basel-Landschaft, Switzerland, 4410