Status:
COMPLETED
Vitamin D Effect in Rheumatoid Arthritis.
Lead Sponsor:
Tanta University
Conditions:
Active Rheumatoid Arthritis
Eligibility:
All Genders
33-60 years
Phase:
PHASE4
Brief Summary
Regulatory T (Tregs) cells play an important role in the maintenance of immunological tolerance. It decrease in the peripheral blood of rheumatoid arthritis patients. Vitamin D has an immunomodulatory...
Detailed Description
Background: Regulatory T cells (Tregs) play an important role in the maintenance of immunological tolerance, so Tregs deficiency or decrease suppressor functions may be associated with development of ...
Eligibility Criteria
Inclusion
- disease duration less than 3 years from the time of diagnosis, age more than 18 years, a diagnosis of RA according to the 2010 ACR/ EULAR Classification criteria for RA diagnosis , active disease according to DAS-28, for those receiving nonsteroidal anti-inflammatory drugs and corticosteroids, the dosage had to be stable for at least 2 weeks before screening.
Exclusion
- Patients with allergic, and infectious diseases, patients receiving steroids for the first time within 2 weeks before the study, patients with hypercalcemia, hypercalciuria, nephrolithiasis, or neoplastic diseases were excluded from the study. We also excluded patients on any biologic therapy and patients with prior use of leflunomide, hydroxychloroquine, or sulphasalazine for more than 2 months.
Key Trial Info
Start Date :
September 6 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 22 2020
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04472481
Start Date
September 6 2019
End Date
March 22 2020
Last Update
July 15 2020
Active Locations (1)
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1
Souzan Ezzat Gado
Tanta, EL-gharbia, Egypt, 31111