Status:
COMPLETED
Prescription Drug Safety and Effectiveness in Multiple Sclerosis
Lead Sponsor:
University of British Columbia
Collaborating Sponsors:
University of Manitoba
Dalhousie University
Conditions:
Multiple Sclerosis
Eligibility:
All Genders
18+ years
Brief Summary
The goal of our research is to find out how safe and effective the drugs used to treat multiple sclerosis (MS) are when used in the everyday, real world. To achieve these study goals, we have two main...
Detailed Description
Study population: A validated case definition of multiple sclerosis (MS) will be applied to the health administrative data to identify all MS patients in 5 Canadian provinces (British Columbia, Manit...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- All MS patients (Studies 1, 2, 4-6) who have resided in one of the 5 Canadian provinces (British Columbia, Manitoba, Nova Scotia, Saskatchewan or Alberta) over the study period as identified using a validated case definition of MS that will be applied to health administrative data (≥ 3 records related to MS coded during physician or hospital visits, or prescription filled for a MS-specific DMDs).
- Subjects require 1 year of residency in a province before study entry to enable sufficient data to facilitate covariate creation, e.g. comorbidity, and to identify those with prior DMD use.
- All adults who visited a MS clinic in British Columbia, Manitoba or Nova Scotia (Study 3), were diagnosed with MS and had a relapsing-onset disease course and at least one EDSS score of 6.5 or less, recorded on or after: January 1st 1996 (British Columbia) or April 1st 1996 (Manitoba) or January 1st 1998 (Nova Scotia).
Exclusion
Key Trial Info
Start Date :
January 1 1996
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 31 2018
Estimated Enrollment :
35000 Patients enrolled
Trial Details
Trial ID
NCT04472975
Start Date
January 1 1996
End Date
March 31 2018
Last Update
May 16 2024
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