Status:
RECRUITING
Everyday Memory Impairment in PD-related Cognitive Decline
Lead Sponsor:
Washington University School of Medicine
Conditions:
Parkinson Disease
Mild Cognitive Impairment
Eligibility:
All Genders
50+ years
Phase:
NA
Brief Summary
The investigators will aim enroll participants into our study within 3-6 months after their parent study visit so the investigators can utilize some key data points (e.g. PD-MCI diagnosis, rs-fcMRI da...
Detailed Description
Parkinson disease (PD) causes cognitive deficits that can impair instrumental activities of daily living function and quality of life (QOL) even in the absence of dementia. Currently, there are no tre...
Eligibility Criteria
Inclusion
- Males and females over age 50 who meet criteria for typical idiopathic PD
- Hoehn \& Yahr stage I-III,
- Treated with levodopa/carbidopa
- Have subjective memory complaints (as identified in phone screen),
- Have an informant to complete relevant ratings,
- Medications should be stable for 4 weeks prior with no changes planned during the treatment portion of the study (Pre to Post); changes over the follow-up period will be tracked and accounted for as appropriate.
Exclusion
- Dementia according to MDS criteria or MoCA score \<21.
- Other neurological disorders (e.g. stroke, seizures), brain surgery, severe systemic diseases, major psychiatric disorder or history of psychotic symptoms (e.g. schizophrenia, bipolar disorder, delusions, hallucinations), or drug abuse.
- Treatment with medications that interfere with cognition (e.g. anticholinergics).
- Any other condition that would interfere with participation (e.g., non-English speaking, significant current depression).
- Psychiatric conditions/ symptoms that are common in PD (e.g. anxiety, depression) are allowed if they are deemed insufficient to interfere with participation.
Key Trial Info
Start Date :
November 29 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2026
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT04474379
Start Date
November 29 2021
End Date
September 1 2026
Last Update
July 17 2025
Active Locations (1)
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1
Washington University School of Medicine
St Louis, Missouri, United States, 63110