Status:
COMPLETED
Reduced Sulfur Diet in Ulcerative Colitis Patients
Lead Sponsor:
University of Calgary
Conditions:
Ulcerative Colitis
Diet Habit
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
A)Background: Approximately 44% of patients with Inflammatory bowel disease have Ulcerative colitis(UC) which is a lifelong, chronic disease, starting in early adulthood, where the colon becomes infl...
Detailed Description
A)Overview and Specific Aims: Higher than normal levels of hydrogen sulfide (H2S) in the colon plays an important role in the etiology of ulcerative colitis (UC). Increased H2S impairs the colonic ce...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Age ≥18 years.
- Currently experiencing a mild or moderate UC flare managed with either ≥1.2 grams of oral 5-ASA, topical 5-ASA, combination oral and topical 5-ASA with or without oral corticosteroid therapy or UC in remission, define by partial Mayo score \< 3, treated with any 5-ASA preparation, or biologic therapies
- Ability to provide informed consent and willingness to undergo 2 endoscopic assessments if flare.
- Exclusion Criteria:
- Experiencing a severe UC flare.
- Have any other major medical comorbidities (diabetes, active malignancy within the past 5 years, active infections, severe respiratory or cardiac disease, or acute or chronic kidney disease).
- Have a history of previous bowel surgery.
- Smokers.
Exclusion
Key Trial Info
Start Date :
April 20 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 30 2021
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT04474561
Start Date
April 20 2016
End Date
March 30 2021
Last Update
April 27 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
TRW building, Foothills, University of Calgary
Calgary, Alberta, Canada, T2N 4Z6