Status:
COMPLETED
Malnutrition in Chronic Gastrointestinal Diseases, Cross-sectional Study
Lead Sponsor:
University Medicine Greifswald
Collaborating Sponsors:
University Medical Center Rostock
University of Applied Sciences Neubrandenburg
Conditions:
Liver Cirrhoses
Chronic Pancreatitis
Eligibility:
All Genders
18+ years
Brief Summary
Malnutrition and muscle wasting are common consequences of life-threatening, chronic diseases of the gastrointestinal tract. Such diseases include liver cirrhosis, chronic pancreatitis and short bowel...
Detailed Description
Malnutrition and sarcopenia are consequences of life-threatening gastroenterological diseases such as liver cirrhosis, chronic pancreatitis and short bowel syndrome and are associated with a poorer cl...
Eligibility Criteria
Inclusion
- Liver Cirrhosis:
- based on clinical and imaging criteria (sonography or computed tomography (CT) or magnetic resonance imaging (MRI)) without evidence of hepatocellular carcinoma
- Child-Pugh Stadium A-C
- Chronic Pancreatitis:
- based on imaging criteria (endoscopic ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), magnetic resonance cholangiopancreatography (MRCP))
- large and small duct disease
- with or without exocrine insufficiency
- with or without endocrine insufficiency
- patients after left pancreatic resection or pancreaticojejunostomy or duodenal pancreatic head resection
- Short Bowel Syndrome (SBS):
- \- based on clinical anamnestic criteria and state after bowel resection followed by primary or secondary oral autonomy (intestinal failure)
- Control Patients:
- patients without known underlying gastroenterological disease with an indication for esophago-gastro-duodenoscopy for symptom clarification
- negative Nutritional Risk Screening (NRS-2002 \< 3)
- gastroscopy without clinically relevant result (mild gastritis aspect, small axial hernia, typical glandular cysts, typical brunneromas can be included)
- Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
Exclusion
- General
Key Trial Info
Start Date :
October 2 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 13 2021
Estimated Enrollment :
345 Patients enrolled
Trial Details
Trial ID
NCT04474743
Start Date
October 2 2018
End Date
September 13 2021
Last Update
November 2 2021
Active Locations (3)
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1
University Medicine Greifswald
Greifswald, Germany, 17475
2
University of Applied Sciences Neubrandenburg
Neubrandenburg, Germany, 17033
3
Univeristy Medicine Rostock
Rostock, Germany, 18057