Status:
TERMINATED
Pre- Versus Post-operative SRS for Resectable Brain Metastases
Lead Sponsor:
AHS Cancer Control Alberta
Conditions:
Brain Metastases
Eligibility:
All Genders
18-100 years
Phase:
PHASE3
Brief Summary
The purpose of this study is to determine if performing radiotherapy (SRS) prior to surgery results in better treatment outcomes than performing surgery before radiotherapy for patients with brain met...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Pathologically-proven primary malignancy
- ECOG 0-2
- Ability to complete neurocognitive testing without assistance from family or friends.
- Previous SRS to lesions other than the one being resected is allowed
- Patients of childbearing / reproductive potential must have a negative urine or serum pregnancy test ≤7 days before enrollment
- Participants capable of giving informed consent, or if appropriate participants having an acceptable individual capable of giving consent
Exclusion
- Patients who have received prior WBRT, or SRS to the lesion being resected at time of study accrual
- Patients unable to undergo MRI scan (e.g. pacemaker)
- Leptomeningeal disease
- Germ cell tumor, small cell lung cancer or hematological primary malignancy
Key Trial Info
Start Date :
September 27 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 7 2025
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT04474925
Start Date
September 27 2021
End Date
April 7 2025
Last Update
July 18 2025
Active Locations (1)
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1
Tom Baker Cancer Centre/Arthur J.E. Child Comprehensive Cancer Centre
Calgary, Alberta, Canada