Status:
UNKNOWN
Impact of Coronary Artery Stenting on Quantitative Myocardial Blood Flow and Health Status
Lead Sponsor:
Cardiovascular Imaging Technologies
Conditions:
Coronary Artery Disease
Eligibility:
All Genders
18-90 years
Brief Summary
We propose to perform PET MPI studies in patients before and after stenting to evaluate changes (or lack thereof) in MBFR and how that is associated with changes (or lack thereof) in symptoms, functio...
Detailed Description
Myocardial perfusion imaging (MPI) has a well-established role in diagnosis, risk stratification and prognostication in patients with suspected or known coronary artery disease (CAD)(1,2). As the curr...
Eligibility Criteria
Inclusion
- The index clinically-indicated rest/regadenoson stress myocardial perfusion PET study shows at least one reversible perfusion defect; and
- The MBFR measurement meets quality control criteria for accuracy; and
- The patient has completed a baseline SAQ-7 and RDS survey with a SAQ-7 Angina Frequency Score \<100 (indicating the occurrence of at least some angina symptoms over the past 4 weeks); and
- The patient has undergone a successful coronary artery stenting within 60 days after the PET scan without a significant change in clinical condition between the time of baseline PET MPI test and PCI; and 5. The patient agrees to undergo a second PET scan 3-6 weeks after coronary artery stenting and to complete a second SAQ-7 and RDS survey.
Exclusion
- EF \<40%
- Significant aortic stenosis/regurgitation
- Significant Mitral stenosis/regurgitation)
- Prior CABG
- Poor quality base line PET study due one or more technical challenges (e.g. patient motion, imprecise registration of CT and emission data, flows that violate quality criteria, lack of flow augmentation suggestive of an A2A antagonist)
Key Trial Info
Start Date :
December 23 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2021
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT04475094
Start Date
December 23 2019
End Date
December 31 2021
Last Update
July 17 2020
Active Locations (1)
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1
Saint Luke's Hospital Imaging Center
Kansas City, Missouri, United States, 64111