Status:
WITHDRAWN
Metabolomics and Wound Healing in Diabetes
Lead Sponsor:
Chang Gung Memorial Hospital
Collaborating Sponsors:
Ministry of Science and Technology, Taiwan
Conditions:
Diabetes Mellitus, Type 2
Infection
Eligibility:
All Genders
40-80 years
Phase:
NA
Brief Summary
The dysfunction of wound healing in diabetes involves multiple healing processes by diminished inflammatory responses and delayed deposition of matrix components, wound remodeling, and closure. Furthe...
Detailed Description
The dysfunction of wound healing in diabetes involves multiple healing processes by diminished inflammatory responses and delayed deposition of matrix components, wound remodeling, and closure. Furthe...
Eligibility Criteria
Inclusion
- are men or non-pregnant women, aged ≥ 40 years or ≤ 80 years
- have a history of foot ulcers for more than 1 month
- have a serum albumin level ≤ 4.0 or an ABI level ≤ 1
Exclusion
- Have active malignancy
- Have acute gastrointestinal surgery
- are receiving dialysis
- have heart failure (NYHA Fc ≥ 3), liver cirrhosis (Child class \> B), or myocardial infarction in the past 3 months,
- have wounds complicated with persistent osteomyelitis or Charcot deformity
- are receiving hydroxyurea or steroid treatment
- have alcohol abuse, any mental or physiological condition that may interfere with dietary intake, and those who are unable to follow orders or cooperate.
Key Trial Info
Start Date :
October 31 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 18 2025
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04475861
Start Date
October 31 2018
End Date
June 18 2025
Last Update
July 17 2020
Active Locations (1)
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1
Chang Gung Memorial Hospital
Taipei, Taiwan, 333