Status:
COMPLETED
Interactions Between Skincare Product Ingredients and the Skin Microbiome
Lead Sponsor:
University of California, Davis
Conditions:
Dysbiosis
Eligibility:
All Genders
15+ years
Phase:
NA
Brief Summary
This is a study of the influence of skincare products containing chemicals such as parabens and phthalates on the skin microbiome.
Detailed Description
Skin serves as a critical barrier between our bodies and the environment and the locus for a diverse and active microbial community. The composition and metabolic activity of the microbial community o...
Eligibility Criteria
Inclusion
- Individuals aged 15 and over
- No known medical conditions that, in the investigator's opinion, may interfere with study participation.
Exclusion
- Individuals who have been on any medication (including antibiotics, probiotics, prebiotics) that has caused a change in current skin composition of interest based on the opinion of the investigator.
- Individuals with systemic antibiotic use within last 60 days.
- Individuals with topical antibiotic use on the test sites within last 30 days
- Individuals unwilling/unable to avoid topical antibiotics, systemic antibiotics, prebiotics, and probiotics during study.
- No other interfering skin products should be used during duration of study. (Paraben-free \& phthalate-free personal product "safe" list will be provided for other uses during study period if needed).
- Individuals unwilling or unable to undergo 1 week wash-in with paraben/phthalate-free products if needed in the opinion of the investigator.
- Female volunteers who are pregnant or are actively breastfeeding or planning a pregnancy within two months. (There is no known concern for risk to fetus but pregnancy can alter the microbiome being studied)
- Female volunteers who have started a new hormonal birth control agent or switched to a hormonal birth control agent within the past 60 days
- Individuals using any interfering skin products in the opinion of the investigator within 2 weeks of enrollment into the study.
- Individuals who have participated in any other clinical studies using the same test sites (face) in the past 14 days
- Individuals with a known history of hypersensitivity to any ingredients to the cosmetic agent that is being assessed
- Individuals who have history of a psychological illness or condition that would interfere with their ability to understand and follow the requirements of the study at the discretion of the investigator.
Key Trial Info
Start Date :
February 11 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 16 2020
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT04476732
Start Date
February 11 2020
End Date
July 16 2020
Last Update
August 3 2020
Active Locations (1)
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1
UC Davis Dermatology Department
Sacramento, California, United States, 95820