Status:
ACTIVE_NOT_RECRUITING
Characterizing Humoral Immune Response to Mosquito Bites
Lead Sponsor:
University of Oxford
Collaborating Sponsors:
National Health and Medical Research Council, Australia
Burnet Institute
Conditions:
Malaria
Dengue
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
The characteristics of the humoral response directed against mosquito saliva antigens are not known precisely. This is a major limitation for using immunological markers as an outcome in epidemiologic...
Detailed Description
This study is a human challenge model with five arms corresponding to controlled exposure to bites of uninfected laboratory-adapted colonies of Anopheles minimus, An. maculatus, An. dirus, Aedes. aegy...
Eligibility Criteria
Inclusion
- Healthy male or female participant judged by a responsible physician with no abnormality identified on a medical evaluation;
- Thai, Burmese or Karen ethnicity;
- Aged ≥ 18 to \<60 years old;
- Living in Mae Sot city for the last 12 months;
- Willing to participate in the activity and able to give informed consent for participating in the study;
- Able to tolerate direct mosquito exposure.
Exclusion
- History of travel in a malaria endemic are (rural village) in the last 12 months, or plan to do so during the study;
- Medication or condition deemed to interfere with the outcome measure by a responsible physician;
- Moderate and severe anemia (haemoglobin concentration less than 110 g/L of blood);
- Hypersensitivity or anaphylaxis to mosquito bites;
- Pregnant women
Key Trial Info
Start Date :
January 21 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2025
Estimated Enrollment :
147 Patients enrolled
Trial Details
Trial ID
NCT04478370
Start Date
January 21 2021
End Date
December 31 2025
Last Update
August 24 2025
Active Locations (1)
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1
Shoklo Malaria Research unit (SMRU)
Mae Sot, Changwat Tak, Thailand, 63110