Status:
UNKNOWN
Prevalence of Non-alcoholic Fatty Liver Disease in Patients With Chronic Kidney Disease in Assiut University Hospitals
Lead Sponsor:
Assiut University
Conditions:
Study of the NAFLD in CKD Patients Using Fibroscan Study
Eligibility:
All Genders
18-80 years
Brief Summary
The aim of our study is: 1. The early detection of NAFLD in CKD patients with different stages (stage I to IV) to avoid progression to liver fibrosis. 2. Evaluation of the relationship between the se...
Detailed Description
Chronic kidney disease (CKD) is defined as presence of reduced glomerular filtration rate (GFR) \< 60 ml/min/ 1.73 m2 and/or evidence of kidney damage (usually indicated by albuminuria or proteinuria)...
Eligibility Criteria
Inclusion
- \- Eighty CKD patients with different stages (stage I to IV) according to the National Kidney Foundation are recruited from inpatients of renal unit in internal medicine department, Assuit university hospitals. Their GFR will assessed by using CKD EPI equation measured as GFR=166 x(s cr/0.7)-1.209X(0.993)age if female, and GFR=163X(s cr/0.9)-1.209x(0.993)age if male. (Andrews et al 2009).
- CKD staging according to GFR by CKD EPI is:
- Stage1 in which GFR\>90 mil/min but evidence of kidney damage.
- Stage 2 GFR 60-89 mil/min.
- Stage 3 GFR 30-95 mil/min.
- Stage 4 GFR 15-29 mil/min.
- Stage 5 GFR\<15 mil/min. The patients will be enrolled from October 2020 to October 2021.
Exclusion
- 1- All Patients with positive hepatitis C virus antibodies. 2- All Patients with positive hepatitis B surface antigen. 3- Congested liver. 4- Drug induced hepatosteatosis (INH, estrogens, methotrexate, steroids, amiodarone, etc.).
- 5- Autoimmune liver diseases. 6- Metabolic liver diseases. 7- Alcoholic liver disease. 8- Malignancy. 9- ESRD (stage V) on hemodialysis. 10- Obesity overweight BMI \> 30. 11- Metabolic syndrome. 12- Type II DM.
Key Trial Info
Start Date :
July 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2021
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04482153
Start Date
July 1 2020
End Date
July 1 2021
Last Update
July 22 2020
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