Status:
COMPLETED
Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Alzheimer Disease
Lead Sponsor:
University of Pennsylvania
Collaborating Sponsors:
National Institutes of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Conditions:
Alzheimer Disease
Eligibility:
All Genders
60-85 years
Phase:
PHASE1
Brief Summary
Impaired verbal communication is a cardinal symptom of Alzheimer Disease (AD) and the source of enormous distress and disability. Effective therapies for this deficit are lacking. In light of the emer...
Detailed Description
TMS is a technique by which a brief electrical current is induced in brain tissue causing a brief suppression of the excitability of the underlying tissue; the technique, which was introduced in the 1...
Eligibility Criteria
Inclusion
- A diagnosis of mild-moderate AD as defined by the National Institute of Aging - Alzheimer's Disease and Related Disorders Association criteria
- Mild-moderate cognitive impairment, indicated by Mini-Mental Status Exam (MMSE) scores between 23 and 15 inclusive
- Must be right handed as defined by the Edinburgh Handedness Inventory
- Must be a native English speaker
- Must be able to understand the nature of the study, and give informed consent
Exclusion
- History of stroke
- History of seizure
- History of any other significant neurologic disease (e.g., ALS)
- Significant depression as defined by the Geriatric Depression Scale.
- Any significant medical disorder that, in the view of the investigators, could threaten the subject's ability to complete the study (e.g., cancer, significant cardiac disease)
- Any contraindications to TMS, including uncontrolled seizures, previous brain surgery, and history of tinnitus
Key Trial Info
Start Date :
February 19 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 31 2024
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT04482179
Start Date
February 19 2020
End Date
August 31 2024
Last Update
September 15 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104