Status:
COMPLETED
Study of the Effects of Overfeeding on Glucocorticoids in Lean and Obese Subjects
Lead Sponsor:
Eleonora Seelig
Collaborating Sponsors:
Novartis
Conditions:
Overweight and Obesity
Eligibility:
MALE
18-40 years
Brief Summary
Investigators suggest that in lean subjects cortisol increases in response to overfeeding and that this increase is blunted in obese subjects. A group of 18 male healthy lean subjects and another grou...
Detailed Description
Obesity is one of the most serious health problems in the 21st century. High energy food and a sedentary lifestyle are driving the current obesity pandemic. These factors activate the hypothalamic-pit...
Eligibility Criteria
Inclusion
- Body mass index (BMI) \>18,5 and \<25 kg/m2
- BMI \>30 kg/m2
Exclusion
- Any clinically significant concomitant diseases in lean subjects
- Any clinically significant concomitant diseases in obese subjects apart from features of the metabolic syndrome (dyslipidemia, arterial hypertension and insulin resistance)
- Lactose intolerance
- Severe food allergy
- Regular alcohol consumption (\>30 g/d)
- Regular fitness training (\>4 hours/week)
- Previous enrolment in a clinical trial within the last 3 months
- Inability or contradictions to undergo the investigated intervention
- Inability to follow the procedures of the study
Key Trial Info
Start Date :
May 14 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 20 2021
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT04482738
Start Date
May 14 2020
End Date
February 20 2021
Last Update
March 23 2022
Active Locations (1)
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1
University Hospital Basel
Basel, Canton of Basel-City, Switzerland, 4031