Status:
COMPLETED
Melatonin to Decrease the Incidence of Postoperative Delirium in Geriatric Patients
Lead Sponsor:
Cairo University
Conditions:
Postoperative Delirium
Eligibility:
All Genders
65+ years
Brief Summary
POD has been reported to be associated with a large number of risk factors: age as POD occurs in 10% to 61% of those aged 65 or older, dementia, impaired left ventricular function, electrolyte disorde...
Detailed Description
POD has been reported to be associated with a large number of risk factors: age as POD occurs in 10% to 61% of those aged 65 or older, dementia, impaired left ventricular function, electrolyte disorde...
Eligibility Criteria
Inclusion
- ASA physical status I-II
Exclusion
- ASA physical status ≥ III.
- Allergy to the study drugs or one of their ingredients
- Patients with Abbreviated Mental Test (AMT) score of\< 6 ,
- illiterate people,
- preoperative sedation score \>4,
- History of alcohol abuse,
- Sensory impairment (blindness, deafness),
- Severe anemia (hematocrit\<27%),
- Intracranial events (stroke, bleeding, infection),
- Fluid or electrolyte disturbances including dehydration, hyponatremia, hypernatremia,
- Acute cardiac events: myocardial infarction, congestive heart failure exacerbation, arrhythmia,
- Acute pulmonary events: asthma or chronic obstructive pulmonary disease exacerbation, pulmonary embolism, hypoxemia, hypercarbia -,Medications Anticonvulsants, Antidepressants, Antihistamines, Antiparkinsonian agents, Antipsychotics. And history of chronic sedative hypnotic use \>3 times/week during a month prior to surgery
Key Trial Info
Start Date :
July 30 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 3 2020
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04483596
Start Date
July 30 2020
End Date
December 3 2020
Last Update
December 22 2020
Active Locations (1)
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1
Cairo University hospitals
Cairo, Manial, Egypt, 12511