Status:
UNKNOWN
MDR-TB Close Contacts Tracing in China (TCCT Study)
Lead Sponsor:
Huashan Hospital
Conditions:
Multidrug Resistant Tuberculosis
Eligibility:
All Genders
18-70 years
Brief Summary
To investigate the incidence of etiologically confirmed or clinically diagnosed active tuberculosis in close contacts of MDR-TB patients.
Detailed Description
This study is a prospective observational cohort study. MDR-TB patients from multi-centers in China were continuously evaluated one by one, their close contacts were screened for elibgility. All subje...
Eligibility Criteria
Inclusion
- The index patient:
- 18-70 years old; 2.Has smear-positive pulmonary tuberculosis with initial laboratory results with resistance to rifampicin confirmed by GeneXpert; 3.Have an identifiable address and stay in the area during the study period.
Exclusion
- Combined extrapulmonary tuberculosis;
- HIV antibody positive and AIDS patients;
- Critically ill patients, and according to the judgment of the research physician, it is impossible to survive for more than 4 months.
- Termination/termination criteria:
- The patient requests to withdraw from the visit;
- Misdiagnosis and error.
- The close contacts:
- Inclusion Criteria:
- Willing to participate in trial treatment and follow-up and can give informed consent;
- Willing to carry out HIV testing;
- More than 6 hours of cohabitation per week in the 2 weeks prior to diagnosis of the index case.
Key Trial Info
Start Date :
July 21 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2022
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT04484129
Start Date
July 21 2020
End Date
December 31 2022
Last Update
July 23 2020
Active Locations (8)
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1
The Third People's Hospital of Shenzhen City
Shenzhen, Guangzhou, China
2
Guiyang Public Health Treatment Center
Guizhou, Guizhou, China
3
Henan Hospital of Infectious Diseases
Zhengzhou, Henan, China
4
Jiangxi Public Health Center
Nanchang, Jiangxi, China