Status:
ACTIVE_NOT_RECRUITING
Maternal-fetal Immune Responses to Fetal Surgery
Lead Sponsor:
Mayo Clinic
Conditions:
Spina Bifida
Congenital Diaphragmatic Hernia
Eligibility:
FEMALE
18-50 years
Brief Summary
Performing surgery in utero on fetuses with certain birth defects has led to significant improvements in outcomes after birth; however, many of these infants are born preterm which can decrease the ef...
Detailed Description
Over 300,000 neonates worldwide die in their first month of life due to a congenital birth defect. Thanks to advancements in diagnostic technology and imaging, the field of fetal surgery was developed...
Eligibility Criteria
Inclusion
- Inclusion Criteria for study group:
- Maternal age ≥18 years
- Pregnant with a congenital anomaly diagnosis AND undergoing fetal intervention in utero
- Delivery planned at Mayo Clinic, Rochester MN
- Inclusion Criteria for control group:
- Maternal age ≥18 years
- Pregnant with normal ultrasound findings
- Delivery planned at Mayo Clinic, Rochester MN
- Exclusion Criteria:
- Delivery planned elsewhere
- Abnormal fetal karyotype
Exclusion
Key Trial Info
Start Date :
March 24 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2025
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04484441
Start Date
March 24 2022
End Date
December 30 2025
Last Update
August 14 2025
Active Locations (3)
Enter a location and click search to find clinical trials sorted by distance.
1
Mayo Clinic in Rochester, Minnesota
Rochester, Minnesota, United States, 55905
2
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229
3
University of Texas Houston
Houston, Texas, United States, 77030