Status:
COMPLETED
Evaluation of Antibody Response to High-Dose Seasonal Influenza Vaccination in Patients With Myeloid Malignancy Receiving Chemotherapy and Healthy Volunteers
Lead Sponsor:
Roswell Park Cancer Institute
Conditions:
Acute Myeloid Leukemia
Myelodysplastic Syndrome
Eligibility:
All Genders
40+ years
Phase:
EARLY_PHASE1
Brief Summary
This pilot research trial studies the antibody response to high-dose seasonal influenza vaccination in patients with myeloid malignancy receiving chemotherapy and healthy volunteers. Evaluating antibo...
Detailed Description
PRIMARY OBJECTIVES: I. To investigate the antibody response to influenza vaccination in patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) receiving hypomethylating agents (...
Eligibility Criteria
Inclusion
- Subject or legal representative must understand the investigational nature of this study and sign an Independent Ethics Committee/Institutional Review Board approved written informed consent form prior to undergoing any investigational biospecimen (blood) collection procedure
- Willing to undergo seasonal influenza vaccination with Fluzone high dose at Roswell Park Cancer Institute within 2 weeks of enrollment of this study
- Estimated survival of 8 weeks or more following enrollment on the study
Exclusion
- Uncontrolled intercurrent illness including, but not limited to, ongoing or active influenza infection or influenza-like-illness
- Women who are attempting pregnancy or known to be pregnant by clinical history or nursing female subjects
- Unwilling or unable to follow protocol requirements
- Use of prednisone \> 10 mg/day (or its equivalent for other steroids) for \> 2 weeks immediately prior to receiving seasonal influenza vaccination
- Received dose of seasonal influenza vaccination prior to enrollment
- Participation at the time of study enrollment in another clinical trial investigating immunotherapeutic agents (like anti-PD1 or anti-PDL1 or anti-CTLA4 antibodies or vaccines); concurrent participation in an observational/non-interventional study or an interventional study investigating tyrosine kinase inhibitor or other targeted agents use is acceptable
- Inability to receive seasonal influenza vaccine due to prior hypersensitivity to eggs, chicken proteins, or any of the vaccine components
- History of a life-threatening reaction to influenza vaccination or to a vaccine containing similar substances
- Personal history of Guillain-Barre syndrome
- Any condition which in the investigator's opinion deems the subject an unsuitable candidate to receive annual influenza vaccination or may potentially affect the response to influenza vaccination
- Adults unable to consent, individuals who are not yet adults (infants, children, and teenagers), women who are known to be pregnant, attempting pregnancy, or nursing women, and prisoners will be excluded from the study
Key Trial Info
Start Date :
October 17 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 7 2022
Estimated Enrollment :
130 Patients enrolled
Trial Details
Trial ID
NCT04484532
Start Date
October 17 2017
End Date
June 7 2022
Last Update
June 6 2023
Active Locations (1)
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1
Roswell Park Cancer Institute
Buffalo, New York, United States, 14263