Status:
RECRUITING
TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers
Lead Sponsor:
Tizona Therapeutics, Inc
Conditions:
Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
TTX-080-001 is a Phase 1, open label, dose escalation and dose expansion clinical study to determine the safety, tolerability, and recommended Phase 2 dose of TTX-080 monotherapy (HLA-G inhibitor) and...
Detailed Description
TTX-080 is a fully human mAb designed to block the interaction of HLA-G with its known ligands, ILT2 and ILT4 molecules. The Phase 1a was an open label, multicenter, dose escalation clinical trial to ...
Eligibility Criteria
Inclusion
- Abbreviated
- Subject with histological diagnosis of advanced/metastatic cancer \[currently enrolling in CRC only\]
- Age 18 years or older, is willing and able to provide informed consent
- Evidence of measurable disease
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1 AND life expectancy of at least 12 weeks
- Abbreviated
Exclusion
- History of allergy or hypersensitivity to study treatment components. Subjects with a history of severe hypersensitivity reaction to any monoclonal antibody
- Use of an investigational agent within 28 days prior to the first dose of study treatment and throughout the study
- Receiving high-dose systemic steroid therapy or any other form of immunosuppressive therapy
- History of severe autoimmune disease
- Uncontrolled intercurrent illness or other active malignancy requiring ongoing treatment
Key Trial Info
Start Date :
July 14 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2027
Estimated Enrollment :
240 Patients enrolled
Trial Details
Trial ID
NCT04485013
Start Date
July 14 2020
End Date
June 1 2027
Last Update
December 26 2025
Active Locations (40)
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1
Arizona Oncology Associates
Tucson, Arizona, United States, 85711
2
University of Southern California
Los Angeles, California, United States, 90033
3
Hoag Memorial Hospital
Newport Beach, California, United States, 92663
4
Rocky Mountain Cancer Centers
Denver, Colorado, United States, 80218