Status:
UNKNOWN
The Effect of Capsaicin-induced Pain on Homeostatic Plasticity in Healthy Human Participants
Lead Sponsor:
Aalborg University
Conditions:
Healthy
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
People suffering from chronic pain exhibit changes in the way the central nervous system processes pain. Some of the changes in the central nervous system are associated with how the brain adapts to t...
Detailed Description
The aim of this study is to investigate the effect of capsaicin-induced pain on homeostatic plasticity. A randomised crossover design will be used to evaluate the effect of capsaicin-induced pain on ...
Eligibility Criteria
Inclusion
- Healthy, aged between 18-60 years, right-handed and can speak and understand English.
Exclusion
- Lack of ability to cooperate
- Chili allergy
- History or present chronic pain or current acute pain
- Pregnancy
- Drug addiction defined as the use of cannabis, opioids or other drugs
- Present and previous neurological disorders such as epilepsy, Alzheimer's disease,
- dementia, stroke, migraine and other headache disorders, multiple sclerosis,
- Parkinson's disease, neuroinfections, brain tumors and head trauma.
- Present or previous musculoskeletal disorders such as tendonitis, degenerative disc disease, mechanical back syndrome, and ruptured/herniated disc.
- Present or previous mental illnesses such as depression, bipolar disorder, and schizophrenia.
- Current use of medications that may affect the trial (e.g. analgesics, anti- inflammatories, anti-depressives)
- Contraindications to TMS application (history of epilepsy, metal implants in head or jaw, etc.)
- Failure to pass the tDCS screening questionnaire
- Failure to pass the "TASS questionnaire"
Key Trial Info
Start Date :
July 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2020
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT04485689
Start Date
July 1 2020
End Date
December 1 2020
Last Update
August 31 2020
Active Locations (1)
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1
Aalborg University
Aalborg, Denmark, 9220