Status:
ACTIVE_NOT_RECRUITING
Postoperative Thrombosis Prevention in Patients With CD
Lead Sponsor:
Huashan Hospital
Conditions:
Cushing Disease
DVT
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Patients with Cushing disease was randomized to 2 groups. After surgery, the patients were managed with mechanical prevention or mechanical prevention plus anticoagulant drugs(LMWH followed by rivarox...
Detailed Description
Cushing disease, caused by ACTH-secreting pituitary adenomas, can lead to serious complications with increased mortality. Minimally invasive surgery is currently the preferred treatment for the diseas...
Eligibility Criteria
Inclusion
- Cushing\'s disease diagnosed and treated with transsphenoid surgery at study centers
Exclusion
- History of VTE before surgery or within 24 hours post-surgery
- Acute bacterial endocarditis
- Major bleeding events
- Thrombocytopenia
- Active gastrointestinal ulcers
- History of stroke
- High risk of bleeding due to clotting abnormalities
- Participation in other clinical trials within the last three months
- Contraindications to rivaroxaban (e.g., renal dysfunction with eGFR \< 50 mL/min)
- Presence of other malignant diseases
- Severe mental or neurological disorders
- Presence of intracranial vascular abnormalities
- Contraindications to mechanical prophylactic anticoagulation
- Pregnancy
- Any other condition that researchers deem inappropriate for study participation.
Key Trial Info
Start Date :
December 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2025
Estimated Enrollment :
206 Patients enrolled
Trial Details
Trial ID
NCT04486859
Start Date
December 1 2020
End Date
July 1 2025
Last Update
July 2 2025
Active Locations (7)
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1
The First Affiliated Hospital of Fujian Medical University
Fuzhou, Fujian, China, 350004
2
The First Affiliated Hospital of Sun Yat sen University
Guangzhou, Guangdong, China, 510000
3
Tongji Hospital
Wuhan, Hubei, China, 430000
4
Huashan Hospital
Shanghai, Shanghai Municipality, China, 200040