Status:
ACTIVE_NOT_RECRUITING
Robot-Assisted Rehabilitation After HIV-Associated Stroke: Botswana
Lead Sponsor:
University of Pennsylvania
Conditions:
HIV/AIDS
Stroke
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
Today, nearly 37 million people are living with HIV (PLHIV) worldwide and 30 to 40% of them will have neurologic complications leading to disability. Our long-term working hypothesis is that an effect...
Detailed Description
We will test the feasibility of affordable robot therapy in three Aims. In Aim 1, we will optimize for the Botswana context, an affordable technology-based robot system with four exercise stations. We...
Eligibility Criteria
Inclusion
- diagnosis of Stroke (at least 3 months post incident) with or without HIV, age over 18;
- medically stable (Able to tolerate therapy and given the determination as able to go through protocol by physician);
- have neurological function between 5 and 24 as defined by the NIH Stroke Scale (NIHSS);
- have no less than moderate cognitive function as defined by the International HIV-Dementia Scale
- Able to give consent.
Exclusion
- unable to give consent;
- severely depressed (Becks Depression Inventory-Fast Screener);
- experiencing excessive pain (Visual Analog Scale (VAS) score greater than 4);
- have severe spasticity ( than 3) in muscle tone in elbow/shoulder/wrist hip/knee/ankle using the Ashworth Scale;
- have total paralysis or muscular contractures of upper or lower extremity;
- have a history of psychiatric disorder or cardiac problems;
- have a history of prior brain injury including lesions to the cerebella or brain stem;
- have open lesions on the upper or lower limbs;
- It is up to the physician to decide if a subject should be excluded due to severe drug and/or alcohol abuse or taking of medication that would impair cognitive ability.
Key Trial Info
Start Date :
October 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2026
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04488250
Start Date
October 1 2020
End Date
May 1 2026
Last Update
July 3 2025
Active Locations (2)
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1
Penn Medicine Rittenhouse
Philadelphia, Pennsylvania, United States, 19146
2
University of Botswana
Gaborone, Botswana