Status:
TERMINATED
Natural History Study of Children and Adults With Neuroendocrine Neoplasms (NEN)s
Lead Sponsor:
National Cancer Institute (NCI)
Conditions:
Neuroendocrine Tumors
Carcinoma, Neuroendocrine
Eligibility:
All Genders
3+ years
Brief Summary
Background: Neuroendocrine neoplasms (NENs) are rare tumors that originate in neuroendocrine cells. NENs can affect almost any part of the body. People with low-grade tumors can live many years. But ...
Detailed Description
Background: * Neuroendocrine neoplasm (NENs) are divided into neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs). These are rare malignancies occurring for example in the gastrointesti...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Enrollment into NCI protocol 19C0016 'Natural History and Biospecimen Acquisition Study for Children and Adults with Rare Solid Tumors'.
- Age greater than or equal to 3 years old
- Ability of subject or parent/guardian to understand and the willingness to sign a written consent document.
- Subjects with:
- -histologically or cytologically documented NENs, OR
- biochemical evidence of neuroendocrine tumor (serum/urinary) based on elevated levels of chromogranin A, pancreatic polypeptide, neuron-specific enolase, vasoactive intestinal polypeptide, serotonin (urinary 5-HIAA), gastrin, somatostatin, catecholamines, metanephrines, calcitonin, fasting insulin, C-peptide (proinsulin), glucagon, anterior pituitary hormones, OR
- Suspicion of NEN (from any site/origin) on axial imaging (CT/MRI/FDG, PET/68Ga-DOTATATE scan, FDOPA PET scan).
- EXCLUSION CRITERIA:
- None
Exclusion
Key Trial Info
Start Date :
November 24 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 11 2023
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04488263
Start Date
November 24 2020
End Date
January 11 2023
Last Update
January 17 2023
Active Locations (1)
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1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892