Status:
UNKNOWN
Identification of Microbiome and Metabolome of Bronchiectasis in Chinese Population.
Lead Sponsor:
Shanghai Pulmonary Hospital, Shanghai, China
Conditions:
Bronchiectasis
Eligibility:
All Genders
Brief Summary
This study aims to investigate the characteristics of gut microbiome and metabolome in non-CF bronchiectasis patients, hoping to explore the underlying mechanisms as well as the influence of gut micro...
Detailed Description
Non-cystic fibrosis bronchiectasis is a chronic airway disease characterized by irreversible and progressive dilation of the large airways, bronchi and bronchioles, which severely impairs the life qua...
Eligibility Criteria
Inclusion
- Written informed consent
- Regular bowel movement: every 2 days - 3 times/ day
- The diagnose of bronchiectasis should refer to "BTS guideline 2010"
Exclusion
- Diagnosis of ABPA
- Pregnancy or lactation
- Active smoking or alcohol using within last 6 months
- HIV infection
- Previous abdominal or rectal surgery
- Diagnosis of chronic gastrointestinal disease, heart disease, diabetes, severe renal insufficiency (GFR \< 30ml/min) or immunodeficiency
- Regular use of the following types of medications (\> 2 times per week) within last 2 months: opium, loperamide antidiarrheal, systemic antihistaminic, metoclopramide, proton pump inhibitor
- Poor compliance or inability to cooperate as judged by the doctor
Key Trial Info
Start Date :
August 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2021
Estimated Enrollment :
160 Patients enrolled
Trial Details
Trial ID
NCT04490447
Start Date
August 1 2019
End Date
September 1 2021
Last Update
February 21 2021
Active Locations (1)
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1
Shanghai Pulmonary Hospital , Tongji University
Shanghai, Shanghai Municipality, China, 200000