Status:
COMPLETED
Mri characterIzation of Troponin Elevation After Cardiac Surgery
Lead Sponsor:
Hospices Civils de Lyon
Conditions:
Cardiac Surgery
Cardiopulmonary Bypass
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Cardiac surgery under cardiopulmonary bypass (CPB) induces myocardial ischemia-reperfusion injury. This myocardial attack is a well-identified independent prognostic factor of postoperative morbidity ...
Eligibility Criteria
Inclusion
- Age ≥ 18 years old
- Aortic valve surgery with CEC: aortic valve replacement, Bentall, Tirone-David, Wheat with foreseeable clamping time of at least 40 minutes.
- Informed consent signed
Exclusion
- Emergency surgery
- Other unconventional heart surgery
- Aorto-coronary bypass associated with surgery
- History of myocardial infarction or severe coronary artery disease, non-valvular hypertrophic cardiomyopathy (MHC) (primary MHC type, Amyloidosis) and myocarditis
- Preoperative alteration of systolic function of the left ventricle (LVEF \<40%)
- Presence of a contraindication to cardiac MRI (claustrophobia, pacemaker or cardiac defibrillator, metallic body, hypersensitivity to gadolinium)
- Patients with a glomerular filtration rate (GFR) \<30 ml / min
- Patients with permanent atrial fibrillation (ACFA) cardiac arrhythmia
- Patients treated with anthracyclines
- Pregnant and / or lactating woman
- Patient under legal protection
- Patient not benefiting from a social security system
- Patient participating in another clinical study that may interfere with the results of this study.
Key Trial Info
Start Date :
December 2 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 12 2023
Estimated Enrollment :
38 Patients enrolled
Trial Details
Trial ID
NCT04490785
Start Date
December 2 2020
End Date
January 12 2023
Last Update
September 10 2025
Active Locations (1)
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1
Hôpital Louis Pradel
Bron, France, 69500